Reduced glutathione system: Role in cancer development, prevention and treatment (Review)

被引：18

作者：

Locigno, R ^{[1
]}

Castronovo, V ^{[1
]}

机构：

[1] Univ Liege, Metastasis Res Lab, B-4000 Liege, Belgium

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2001年 / 19卷 / 02期

关键词：

glutathione; GSH; antioxidant; cancer;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Reduced glutathione (GSH), a ubiquitous thiolcontaining tripeptide, is unanimously recognized to play a central role in cell biology. It is highly implicated in the cellular defense against xenobiotics and naturally occurring deleterious compounds such as free radicals and hydroperoxides. Consequently, GSH is an essential actor in several human diseases including cancer and cardio-vascular diseases. Its implication in oncogenesis has led to the development of new strategies to improve both prevention and treatment of cancer. The present review proposes an in depth analysis or our current knowledge of the relations between GSH and cancer.

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收藏

页码：221 / 236

页数：16

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