Meiotic recombination hot spots and human DNA diversity

被引：67

作者：

Jeffreys, AJ ^{[1
]}

Holloway, JK ^{[1
]}

Kauppi, L ^{[1
]}

May, CA ^{[1
]}

Neumann, R ^{[1
]}

Slingsby, MT ^{[1
]}

Webb, AJ ^{[1
]}

机构：

[1] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES | 2004年 / 359卷 / 1441期

关键词：

recombination; crossover; conversion; hot spot; haplotype; linkage disequilibrium;

D O I：

10.1098/rstb.2003.1372

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Meiotic recombination plays a key role in the maintenance of sequence diversity in the human genome. However, little is known about the fine-scale distribution and processes of recombination in human chromosomes, or how these impact on patterns of human diversity. We have therefore developed sperm typing systems that allow human recombination to be analysed at very high resolution. The emerging picture is that human crossovers are far from randomly distributed but instead are targeted into very narrow hot spots that can profoundly influence patterns of haplotype diversity in the human genome. These hot spots provide fundamental information on processes of human crossover and gene conversion, as well as evidence that they can violate basic rules of Mendelian inheritance.

引用

页码：141 / 152

页数：12

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