Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines

被引：53

作者：

Alvarado-Sansininea, Jesus J. ^{[1
]}

Sanchez-Sanchez, Luis ^{[2
]}

Lopez-Munoz, Hugo ^{[2
]}

Escobar, Maria L. ^{[3
]}

Flores-Guzman, Fernando ^{[2
]}

Tavera-Hernandez, Rosario ^{[1
]}

Jimenez-Estrada, Manuel ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Dept Prod Nat, Lab 2 10, Mexico City 04510, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Lab 6, UMIEZ, Fac Estudios Superiores Zaragoza, 2do Piso, Mexico City 09230, DF, Mexico

[3] Univ Nacl Autonoma Mexico, Lab Microscopia Elect, Dept Biol Celular, Fac Ciencias, Mexico City 04510, DF, Mexico

来源：

MOLECULES | 2018年 / 23卷 / 10期

关键词：

necrotic; apoptosis; quercetin; quercetagetin; patuletin; COLON-CANCER CELLS; TAGETES-ERECTA; IN-VITRO; FLAVONOIDS; QUERCETIN; CYTOTOXICITY; INHIBITION; POTENT; PLANTS;

D O I：

10.3390/molecules23102579

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Quercetagetin and patuletin were extracted by the same method from two different Tagetes species that have multiple uses in folk medicine in Mexico and around the globe, one of which is as an anticancer agent. Their biological activity (IC50 and necrotic, apoptotic and selective activities of these flavonols) was evaluated and compared to that of quercetin, examining specifically the effects of C6 substitution among quercetin, quercetagetin and patuletin. We find that the presence of a methoxyl group in C6 enhances their potency.

引用

页数：18

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