Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules

被引：336

作者：

Russel, Frans G. M. ^{[1
]}

Koenderink, Jan B. ^{[1
]}

Masereeuw, Rosafinde ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Pharmacol & Toxicol, Nijmegen Ctr Mol Life Sci, NL-6525 GA Nijmegen, Netherlands

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2008年 / 29卷 / 04期

关键词：

D O I：

10.1016/j.tips.2008.01.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Multidrug resistance protein (MRP) 4 is a member of the MRP/ABCC subfamily of ATP-binding cassette transporters, which are capable of pumping a wide variety of endogenous and xenobiotic organic anionic compounds out of the cell. In addition to its role in the body distribution and renal excretion of a wide variety of antiviral, cytostatic, antibiotic and cardiovascular drugs, MRP4/ ABCC4 has the remarkable ability to transport molecules involved in cellular signalling. These molecules include cyclic nucleotides, eicosanoids, urate and conjugated steroids. The unique structure, regulation and dual localisation of MRP4 in polarised cells could be connected with a key function in cellular protection and extracellular signalling pathways. This review focuses on recent insights into the versatile transport function of MRP4 and its potential as a new therapeutic target to modulate various pathophysiological signalling processes.

引用

页码：200 / 207

页数：8

共 63 条

[1] Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2 [J].

Aleksunes, Lauren M. ;

Slitt, Angela L. ;

Maher, Jonathan M. ;

Augustine, Lisa M. ;

Goedken, Michael J. ;

Chan, Jefferson Y. ;

Cherrington, Nathan J. ;

Klaassen, Curtis D. ;

Manautou, Jose E. .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2008, 226 (01) :74-83

[2] New insights into renal transport of urate [J].

Anzai, Naohiko ;

Kanai, Yoshikatsu ;

Endou, Hitoshi .

CURRENT OPINION IN RHEUMATOLOGY, 2007, 19 (02) :151-157

[3] Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice [J].

Assem, M ;

Schuetz, EG ;

Leggas, M ;

Sun, DX ;

Yasuda, K ;

Reid, G ;

Zelcer, N ;

Adachi, M ;

Strom, S ;

Evans, RM ;

Moore, DD ;

Borst, P ;

Schuetz, JD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (21) :22250-22257

[4] Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage [J].

Belinsky, Martin G. ;

Guo, Ping ;

Lee, Kun ;

Zhou, Feng ;

Kotova, Elena ;

Grinberg, Alex ;

Westphal, Heiner ;

Shchaveleva, Irina ;

Klein-Szanto, Andres ;

Gallo, James M. ;

Kruh, Gary D. .

CANCER RESEARCH, 2007, 67 (01) :262-268

[5] Multidrug resistance-associated proteins 3, 4, and 5 [J].

Borst, Piet ;

de Wolf, Cornelia ;

de Wetering, Koen van .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2007, 453 (05) :661-673

[6] Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate cancer cells [J].

Cai, C. ;

Omwancha, J. ;

Hsieh, C-L ;

Shemshedini, L. .

PROSTATE CANCER AND PROSTATIC DISEASES, 2007, 10 (01) :39-45

[7] Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR- rats [J].

Chen, CA ;

Slitt, AL ;

Dieter, MZ ;

Tanaka, Y ;

Scheffer, GL ;

Klaassen, CD .

BIOCHEMICAL PHARMACOLOGY, 2005, 70 (07) :1088-1095

[8]

Chen ZS, 2002, CANCER RES, V62, P3144

[9] Transport of cyclic nucleotides and estradiol 17-β-D-glueuronide by multidrug resistance protein 4 -: Resistance to 6-mercaptopurine and 6-thioguanine [J].

Chen, ZS ;

Lee, K ;

Kruh, GD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (36) :33747-33754

[10] Characterization of mice lacking the multidrug resistance protein Mrp2 (Abcc2) [J].

Chu, XY ;

Strauss, JR ;

Mariano, MA ;

Li, J ;

Newton, DJ ;

Cai, XX ;

Wang, RW ;

Yabut, J ;

Hartley, DP ;

Evans, DC ;

Evers, R .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2006, 317 (02) :579-589

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