Total synthesis of (+)-neopeltolide

被引：83

作者：

Fuwa, Haruhiko ^{[1
]}

Naito, Shinya ^{[1
]}

Goto, Tomomi ^{[1
]}

Sasaki, Makoto ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Life Sci, Lab Biostruct Chem, Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 25期

关键词：

macrolides; natural products; ring-closing metathesis; Suzuki-Miyaura coupling; total synthesis;

D O I：

10.1002/anie.200801399

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Rapid elaboration: (+)-Neopeltolide, a novel marine metabolite with potent cytotoxicity against several cancer cell lines, was the target of an efficient total synthesis (see scheme). The construction of the 2,4,6-trisubstituted tetrahydropyran substructure is based on a Suzuki-Miyaura coupling/ring-closing metathesis sequence. BOM = benzyloxymethyl, MPM = 4-methoxyphenylmethyl, TIPS = triisopropylsilyl. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4737 / 4739

页数：3

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