Bidirectional signaling between the cytoskeleton and integrins

被引：641

作者：

Schoenwaelder, SM

Burridge, K

机构：

[1] Univ N Carolina, Dept Cell Biol & Anat, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(99)80037-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Clustering of integrins into focal adhesions and focal complexes is regulated by the actin cytoskeleton. In turn, actin dynamics are governed by Rho family GTPases, Integrin-mediated adhesion activates these GTPases, triggering assembly of filopodia, lamellipodia and stress fibers. In the past few years, signaling pathways have begun to be identified that promote focal adhesion disassembly and integrin dispersal, Many of these pathways result in decreased myosin-mediated cell contractility.

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收藏

页码：274 / 286

页数：13

相关论文

共 157 条

[1] Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein [J].

Altun-Gultekin, ZF ;

Chandriani, S ;

Bougeret, C ;

Ishizaki, T ;

Narumiya, S ;

de Graaf, P ;

Henegouwen, PVE ;

Hanafusa, H ;

Wagner, JA ;

Birge, RB .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (05) :3044-3058

[2] Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase [J].

Amano, M ;

Chihara, K ;

Kimura, K ;

Fukata, Y ;

Nakamura, N ;

Matsuura, Y ;

Kaibuchi, K .

SCIENCE, 1997, 275 (5304) :1308-1311

[3] Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase) [J].

Amano, M ;

Ito, M ;

Kimura, K ;

Fukata, Y ;

Chihara, K ;

Nakano, T ;

Matsuura, Y ;

Kaibuchi, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (34) :20246-20249

[4] Impaired integrin-mediated adhesion and signaling in fibroblasts expressing a dominant-negative mutant PTP1B [J].

Arregui, CO ;

Balsamo, J ;

Lilien, J .

JOURNAL OF CELL BIOLOGY, 1998, 143 (03) :861-873

[5] Two GTPases, cdc42 and rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome [J].

Aspenstrom, P ;

Lindberg, U ;

Hall, A .

CURRENT BIOLOGY, 1996, 6 (01) :70-75

[6] Requirement for Rho in integrin signalling [J].

Barry, ST ;

Flinn, HM ;

Humphries, MJ ;

Critchley, DR ;

Ridley, AJ .

CELL ADHESION AND COMMUNICATION, 1996, 4 (06) :387-398

[7] IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments [J].

Bashour, AM ;

Fullerton, AT ;

Hart, MJ ;

Bloom, GS .

JOURNAL OF CELL BIOLOGY, 1997, 137 (07) :1555-1566

[8] Involvement of microtubules in the control of adhesion-dependent signal transduction [J].

Bershadsky, A ;

Chausovsky, A ;

Becker, E ;

Lyubimova, A ;

Geiger, B .

CURRENT BIOLOGY, 1996, 6 (10) :1279-1289

[9] PSEUDOPODIAL ACTIVITY AT THE ACTIVE EDGE OF MIGRATING FIBROBLAST IS DECREASED AFTER DRUG-INDUCED MICROTUBULE DEPOLYMERIZATION [J].

BERSHADSKY, AD ;

VAISBERG, EA ;

VASILIEV, JM .

CELL MOTILITY AND THE CYTOSKELETON, 1991, 19 (03) :152-158

[10] Identification of p130(Cas) as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions [J].

Black, DS ;

Bliska, JB .

EMBO JOURNAL, 1997, 16 (10) :2730-2744

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