Dynamics of monocyte chemoattractant protein type one (MCP-1) and HIV viral load in human cerebrospinal fluid and plasma

被引：41

作者：

de Almeida, SN ^{[1
]}

Letendre, S ^{[1
]}

Zimmerman, J ^{[1
]}

Lazzaretto, D ^{[1
]}

McCutchan, A ^{[1
]}

Ellis, R ^{[1
]}

机构：

[1] Univ Calif San Diego, HIV Neurobehav Res Ctr, San Diego, CA 92103 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 169卷 / 1-2期

关键词：

MCP-1; chemokines; cerebrospinal fluid; HIV; central nervous system;

D O I：

10.1016/j.jneuroim.2005.07.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Increased expression of monocyte chemoattractant protein type 1 (MCP-1) is associated with HIV CNS disease. This Study evaluated the temporal relationships between MCP-1 expression and HIV replication in the CNS. Methods: MCP-1 and HIV viral load (VL) were measured in serially obtained samples of plasma and cerebrospinal fluid (CSF) in subjects either interrupting (TI) or starting (TS) antiretroviral therapy. Results: Following Tl, plasma VL rebounded first, followed by increases in CSF MCP-1, which immediately preceded or coincided with a rebound of CSF VL. Conclusion: The close temporal relationship of the increase of MCP-1 and CSF VL suggests that they are co-regulated, or that one is a stimulus for the other. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：144 / 152

页数：9

共 31 条

[1] Regulation of MCP-1 gene transcription by Smads and HIV-1 Tat in human glial cells [J].

Abraham, S ;

Sawaya, BE ;

Safak, M ;

Batuman, O ;

Khalili, K ;

Amini, S .

VIROLOGY, 2003, 309 (02) :196-202

[2] Characterization of chemokines and their receptors in the central nervous system: physiopathological implications [J].

Bajetto, A ;

Bonavia, R ;

Barbero, S ;

Schettini, G .

JOURNAL OF NEUROCHEMISTRY, 2002, 82 (06) :1311-1329

[3] Chemokines and their receptors in the central nervous system [J].

Bajetto, A ;

Bonavia, R ;

Barbero, S ;

Florio, T ;

Schettini, G .

FRONTIERS IN NEUROENDOCRINOLOGY, 2001, 22 (03) :147-184

[4] Chemokines in the brain: neuroimmunology and beyond [J].

Biber, K ;

Zuurman, MW ;

Dijkstra, IM ;

Boddeke, HWGM .

CURRENT OPINION IN PHARMACOLOGY, 2002, 2 (01) :63-68

[5] Highly active antiretroviral therapy normalizes the potential for MIP-1α production in HIV infection [J].

Carter, LM ;

Peters, BS ;

Ellis, BA ;

Wolstencroft, RA .

JOURNAL OF INFECTION, 2000, 41 (03) :252-255

[6]

Chang L, 2004, ANTIVIR THER, V9, P431

[7] Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication [J].

Cinque, P ;

Vago, L ;

Mengozzi, M ;

Torri, V ;

Ceresa, D ;

Vicenzi, E ;

Transidico, P ;

Vagani, A ;

Sozzani, S ;

Mantovani, A ;

Lazzarin, A ;

Poli, G .

AIDS, 1998, 12 (11) :1327-1332

[8] Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia [J].

Conant, K ;

Garzino-Demo, A ;

Nath, A ;

McArthur, JC ;

Halliday, W ;

Power, C ;

Gallo, RC ;

Major, EO .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (06) :3117-3121

[9] Endogenous CCL2 (monocyte chemotactic protein-1) modulates human immunodeficiency virus type-1 replication and affects cytoskeleton organization in human monocyte-derived macrophages [J].

Fantuzzi, L ;

Spadaro, F ;

Vallanti, G ;

Canini, I ;

Ramoni, C ;

Vicenzi, E ;

Belardelli, F ;

Poli, G ;

Gessani, S .

BLOOD, 2003, 102 (07) :2334-2337

[10] The amino-terminal domain of the CCR2 chemokine receptor acts as coreceptor for HIV-1 infection [J].

Frade, JMR ;

Llorente, M ;

Mellado, M ;

Alcami, J ;

GutierrezRamos, JC ;

Zaballos, A ;

delReal, G ;

MartinezA, C .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (03) :497-502

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