Industrial-scale, genomics-based drug design and discovery

被引：46

作者：

Dean, PM ^{[1
]}

Zanders, ED ^{[1
]}

Bailey, DS ^{[1
]}

机构：

[1] De Novo Pharmaceut Ltd, Cambridge CB2 3DD, England

来源：

TRENDS IN BIOTECHNOLOGY | 2001年 / 19卷 / 08期

关键词：

D O I：

10.1016/S0167-7799(01)01696-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The demands on drug discovery organizations have increased dramatically in recent years, partly because of the need to identify novel targets that are both relevant to disease and chemically tractable. This is leading to an industrial approach to traditional biology and chemistry, inspired in part by the revolution in genomics. The purpose of this article is to highlight the flow of investigation from gene sequence of potential therapeutic targets, through mRNA and protein expression, to protein structure and drug design. To deal with this scale of activity, many commercial and public organizations have been established and some of the key players will be listed in this article.

引用

页码：288 / 292

页数：5

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