Biological markers for axonal degeneration in CSF and blood of patients with the first event indicative for multiple sclerosis

被引：75

作者：

Hein , Katharina ^{[1
]}

Koehler, Anushka ^{[1
]}

Diem, Ricarda ^{[2
]}

Saettler, Muriel B. ^{[1
]}

Demmer, Iris ^{[1
]}

Lange, Peter ^{[1
]}

Baehr, Mathias ^{[1
]}

Otto, Markus ^{[3
]}

机构：

[1] Neurol Univ Klin, D-37075 Gottingen, Germany

[2] Neurol Univ Klin, Hamburg, Germany

[3] Neurol Univ Klin, Ulm, Germany

来源：

NEUROSCIENCE LETTERS | 2008年 / 436卷 / 01期

关键词：

multiple sclerosis; axonal damage; biomarkers; cerebrospinal fluid; neuron specific enolase;

D O I：

10.1016/j.neulet.2008.02.064

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Axonal degeneration is now recognized as an important pathological feature of multiple sclerosis (MS). Acute axonal damage happens early in the disease course, and therefore early changes might occur in markers in body fluids, such as cerebrospinal fluid (CSF) and blood. In our study we investigated the relevance of serum and CSF markers for axonal damage in patients with clinically isolated syndrome indicative for MS. We measured the concentration of tau, phospho-tau, S100B, Amyloid beta and neuron specific enolase (NSE) in CSF and serum. Interestingly, the NSE concentration in CSF and serum was decreased in clinically isolated syndrome (CIS)-patients in comparison to the control group indicating reduced neuronal metabolic activity in the early stage of the disease. Concerning other biomarkers, we did not observe any changes in the concentrations between groups. Moreover, we did not detect any correlation between Expanded Disability Status Scale (EDSS) and the concentration of investigated proteins. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：72 / 76

页数：5

共 39 条

[1]

BINDER LI, 1985, J CELL BIOL, V101, P1371, DOI 10.1083/jcb.101.4.1371

[2] Tau protein level in cerebrospinal fluid is increased in patients with early multiple sclerosis [J].