Aspergillus meningitis:: Diagnosis by non-culture-based microbiological methods and management

被引:111
作者
Verweij, PE
Brinkman, K
Kremer, HPH
Kullberg, BJ
Meis, JFGM
机构
[1] Univ Nijmegen Hosp, Dept Med Microbiol, NL-6500 HB Nijmegen, Netherlands
[2] Univ Nijmegen Hosp, Dept Internal Med, NL-6500 HB Nijmegen, Netherlands
[3] Univ Nijmegen Hosp, Dept Neurol, NL-6500 HB Nijmegen, Netherlands
关键词
D O I
10.1128/JCM.37.4.1186-1189.1999
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The performance of antibody detection, antigen detection, and Aspergillus genus-specific PCR fur diagnosing Aspergillus meningitis was investigated with 26 cerebrospinal fluid (CSF) samples obtained from a single patient with proven infection caused by Aspergillus fumigatus. Immunoglobulin G antibodies directed against Aspergillus were not detected by enzyme-linked immunosorbent assay in CSF or serum. The antigen galactomannan was detected in the CSF 45 days before a culture became positive, and Aspergillus DNA was detected 4 days prior to culture, Decline of the galactomannan antigen titer in the CSF during treatment with intravenous and intraventricular amphotericin B and intravenous voriconazole corresponded with the clinical response to treatment.
引用
收藏
页码:1186 / 1189
页数:4
相关论文
共 34 条
[1]   Aspergillus flavus meningitis and pontine hemorrhage in an older patient [J].
Adunsky, A ;
Rubinstein, E ;
Goldsmith, A .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1996, 44 (06) :739-740
[2]   5-FLUOROCYTOSINE TREATMENT OF MENINGEAL AND PULMONARY ASPERGILLOSIS [J].
ATKINSON, GW ;
ISRAEL, HL .
AMERICAN JOURNAL OF MEDICINE, 1973, 55 (04) :496-504
[3]   ASPERGILLOSIS OF THE NERVOUS-SYSTEM [J].
BEAL, MF ;
OCARROLL, CP ;
KLEINMAN, GM ;
GROSSMAN, RI .
NEUROLOGY, 1982, 32 (05) :473-479
[4]  
CAMARATA PJ, 1992, NEUROSURGERY, V31, P575, DOI 10.1097/00006123-199209000-00023
[5]   AMPHOTERICIN B-INDUCED MYELOPATHY [J].
CARNEVALE, NT ;
GALGIANI, JN ;
STEVENS, DA ;
HERRICK, MK ;
LANGSTON, JW .
ARCHIVES OF INTERNAL MEDICINE, 1980, 140 (09) :1189-1192
[6]  
COLEMAN JM, 1995, NEUROSURGERY, V36, P858, DOI 10.1097/00006123-199504000-00032
[7]  
DENNING D, 1995, 35 INT C ANT AG CHEM, P126
[8]  
DENNING DW, 1990, REV INFECT DIS, V12, P1147
[9]   Novel antifungal 2-aryl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives with high activity against Aspergillus fumigatus. [J].
Dickinson, RP ;
Bell, AS ;
Hitchcock, CA ;
Narayanaswami, S ;
Ray, SJ ;
Richardson, K ;
Troke, PF .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (16) :2031-2036
[10]   ASPERGILLOSIS OF THE NERVOUS-SYSTEM - REPORT OF 2 CASES [J].
DIENGDOH, JV ;
BARNARD, RO ;
THOMAS, DGT .
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1983, 9 (06) :477-484