Innate sensors of microbial infection

被引：80

作者：

Hargreaves, DC ^{[1
]}

Medzhitov, R

机构：

[1] Yale Univ, Sch Med, HHMI, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Sect Immunobiol, New Haven, CT USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2005年 / 25卷 / 06期

关键词：

pattern recognition receptor; toll-like receptor; NOD1 and NOD2; RIG-I and MDA-5;

D O I：

10.1007/s10875-005-8065-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The innate immune system utilizes multiple families of pattern-recognition receptors (PRRs) to protect the host from infection. Each of these families contributes certain elements to the complement of innate effector functions that is elicited during an infection. Here we review the families of PRRs and explore examples of their cooperativity.

引用

页码：503 / 510

页数：8

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