A novel endogenous retrovirus-related element in the human genome resembles a DNA transposon: Evidence for an evolutionary link?

被引：19

作者：

Hughes, JF

Coffin, JM

机构：

[1] Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA

[2] Tufts Univ, Sch Med, Genet Program, Boston, MA 02111 USA

[3] Amer Canc Soc, Atlanta, GA 30329 USA

来源：

GENOMICS | 2002年 / 80卷 / 05期

关键词：

D O I：

10.1006/geno.2002.6856

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A significant fraction of the human genome is composed of various types of transposable elements, which are divided into two broad classes based on their mechanism of transposition: via an RNA intermediate (retroelements) or via a DNA intermediate (DNA transposons). The retroelements, which include endogenous retroviruses, are the more prominent group in humans and seem to be restricted to eukaryotes. DNA transposons are known in almost all well-studied organisms, including bacteria. In the human genome, they exist as mere fossils and seem to have been inactive for millions of years. We report here an element in the human genome that is the pro duct of a recent retro-transposition event, yet apparently, by a novel mechanism of reverse transcription, has acquired inverted repeats more characteristic of DNA transposons.

引用

页码：453 / 455

页数：3

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