Assembly and export of MHC class I peptide ligands

被引：88

作者：

Antoniou, AN ^{[1
]}

Powis, SJ

Elliott, T

机构：

[1] Univ Dundee, Sch Life Sci, Div Cell Biol & Immunol, Dundee DD1 5EH, Scotland

[2] Univ Southampton, Southampton Gen Hosp, Sch Med, Canc Sci Div, Southampton SO16 6YD, Hants, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(02)00010-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC class I-specific accessory molecules. These interactions culminate in the trafficking of MHC class I molecules to the cell surface and presentation of peptide to CD8(+) T lymphocytes. Recent studies have revealed just how important these early interactions are, and how they influence the quality control of assembly and the optimisation of peptide-ligand binding.

引用

页码：75 / 81

页数：7

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