p21-activated kinase signaling in breast cancer

被引:17
作者
Gururaj, AE [1 ]
Rayala, SK [1 ]
Kumar, R [1 ]
机构
[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA
关键词
breast cancer; hormone independence; mouse model; p21-activated kinase; Rho GTPase;
D O I
10.1186/bcr961
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The p21-activated kinases signal through a number of cellular pathways fundamental to growth, differentiation and apoptosis. A wealth of information has accumulated at an impressive pace in the recent past, both with regard to previously identified targets for p21-activated kinases that regulate the actin cytoskeleton and cellular stress pathways and with regard to newly identified targets and their role in cancer. Emerging data also provide new clues towards a previously unappreciated link between these various cellular processes. The present review attempts to provide a quick tutorial to the reader about the evolving significance of p21-activated kinases and small GTPases in breast cancer, using information from mouse models, tissue culture studies, and human materials.
引用
收藏
页码:5 / 12
页数:8
相关论文
共 79 条
[1]   Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase [J].
Adam, L ;
Vadlamudi, R ;
Kondapaka, SB ;
Chernoff, J ;
Mendelsohn, J ;
Kumar, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (43) :28238-28246
[2]   Overexpression of βPix-a in human breast cancer tissues [J].
Ahn, SJ ;
Chung, KW ;
Lee, RA ;
Park, IA ;
Lee, SH ;
Park, DE ;
Noh, DY .
CANCER LETTERS, 2003, 193 (01) :99-107
[3]   Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-β1-mediated angiogenesis [J].
Bagheri-Yarmand, R ;
Vadlamudi, RK ;
Wang, RA ;
Mendelsohn, J ;
Kumar, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (50) :39451-39457
[4]   Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells [J].
Bagheri-Yarmand, R ;
Mandal, M ;
Taludker, AH ;
Wang, RA ;
Vadlamudi, RK ;
Kung, HJ ;
Kumar, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (31) :29403-29409
[5]   Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells [J].
Balasenthil, S ;
Barnes, CJ ;
Rayala, SK ;
Kumar, R .
FEBS LETTERS, 2004, 567 (2-3) :243-247
[6]   p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells [J].
Balasenthil, S ;
Sahin, AA ;
Barnes, CJ ;
Wang, RA ;
Pestell, RG ;
Vadlamudi, RK ;
Kumar, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (02) :1422-1428
[7]   Pak1 phosphorylation on T212 affects microtubules in cells undergoing mitosis [J].
Banerjee, M ;
Worth, D ;
Prowse, DM ;
Nikolic, M .
CURRENT BIOLOGY, 2002, 12 (14) :1233-1239
[8]   Functional inactivation of a transcriptional corepressor by a signaling kinase [J].
Barnes, CJ ;
Vadlamudi, RK ;
Mishra, SK ;
Jacobson, RH ;
Li, F ;
Kumar, R .
NATURE STRUCTURAL BIOLOGY, 2003, 10 (08) :622-628
[9]   Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho [J].
Bayless, KJ ;
Davis, GE .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (12) :11686-11695
[10]   Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma [J].
Bekri, S ;
Adélaïde, J ;
Merscher, S ;
Grosgeorge, J ;
Caroli-Bosc, F ;
Perucca-Lostanlen, D ;
Kelley, PM ;
Pébusque, MJ ;
Theillet, C ;
Birnbaum, D ;
Gaudray, P .
CYTOGENETICS AND CELL GENETICS, 1997, 79 (1-2) :125-131