Anemia in β-thalassemia patients targets hepatic hepcidin transcript levels independently of iron metabolism genes controlling hepcidin expression

被引：26

作者：

Camberlein, Emilie ^{[1
]}

Zanninelli, Giuliana ^{[2
]}

Detivaud, Lenaick ^{[1
]}

Lizzi, Anna Rita ^{[2
]}

Sorrentino, Francesco ^{[2
]}

Vacquer, Stefania ^{[4
]}

Troadec, Marie-Berengere ^{[1
]}

Angelucci, Emanuele ^{[3
]}

Abgueguen, Emmanuelle ^{[1
]}

Loreal, Olivier ^{[1
]}

Cianciulli, Paolo ^{[2
]}

Lai, Maria Eliana ^{[4
]}

Brissot, Pierre ^{[1
]}

机构：

[1] Univ Hosp Pontchaillou, Inserm U522, IFR 140, Rennes, France

[2] Day Hosp Talassemie, Osped San Eugenio, Rome, Italy

[3] Osped Oncol, Div Ematol, Cagliari, Italy

[4] Univ Cagliari, Osped Regionale Microcitemie, Ctr Talassem Adulti, Dipartimento Sci Med, Cagliari, Italy

来源：

HAEMATOLOGICA | 2007年 / 93卷 / 01期

关键词：

anemia; beta-thalassemia; hepcidin; gene expression; iron overload;

D O I：

10.3324/haematol.11656

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thalassemia associates anemia and iron overload, two opposite stimuli regulating hepcidin gene expression. We characterized hepatic hepcidin expression in 10 thalassemia major and 13 thalassemia intermedia patients. Hepcidin mRNA levels were decreased in the thalassemia intermedia group which presented both lower hemoglobin and higher plasma soluble transferrin receptor levels. There was no relationship between hepcidin mRNA levels and those of genes controlling iron metabolism, including HFE, hemojuvelin, transferrin receptor-2 and ferroportin. These results underline the role of erythropoietic activity on hepcidin decrease in thalassemic patients and suggest that mRNA modulations of other studied genes do not have a significant impact.

引用

页码：111 / 115

页数：5

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