The Trp64Arg polymorphism of the β 3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort

被引:80
作者
Büettner, R [1 ]
Schäffler, A [1 ]
Arndt, H [1 ]
Rogler, G [1 ]
Nusser, J [1 ]
Zietz, B [1 ]
Enger, I [1 ]
Hügl, S [1 ]
Cuk, A [1 ]
Schölmerich, J [1 ]
Palitzsch, KD [1 ]
机构
[1] Univ Regensburg, Dept Internal Med 1, D-93042 Regensburg, Germany
关键词
D O I
10.1210/jc.83.8.2892
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The beta 3-adrenergic receptor (3-BAR) is assumed to play a role in the regulation of energy balance by increasing lipolysis and thermogenesis. A recently detected allelic polymorphism (Trp64Arg polymorphism) has been suggested to contribute to the development of obesity and non-insulin-dependent diabetes mellitus. We examined the prevalence of the two 3-BAR alleles in Germany and looked for associations between 3-BAR genotype and metabolic disorders (obesity and type 2 diabetes mellitus). From over 6450 participants in the Diabetomobile Study, a nationwide epidemiologic study on the prevalence of metabolic disorders (carried out from 1993 to 1996 in Germany), 1259 participants were randomly chosen. The 3-BAR genotype status was determined by 3-BAR gene-specific genomic PCR and consecutive restriction fragment length polymorphism analysis. The frequencies of the different genotypes in the examined cohort were as follows: Trp64/Trp64, 88.3%; Trp64/Arg64, 10.8%; and Arg64/ Arg64, 0.8%. No significant differences between the different genotypes were found when comparing age, body mass index, weight, total and high-density lipoprotein (HDL) cholesterol, fasting insulin, HbA1(c), and blood pressure; neither did the type 2 diabetes mellitus participants in the different genotype groups differ significantly in terms of age of diabetes onset or HbA1(c). This is the largest population-based study on the Trp64Arg polymorphism reported yet. The Arg64 allele of the 3-BAR gene was found commonly in Germany. In our cohort, no significant associations between the Arg64 allele and metabolic disorders (e.g. obesity, type 2 diabetes mellitus, dyslipidemia, or hypertension) were detected.
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页码:2892 / 2897
页数:6
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