Innate recognition of viruses

被引：579

作者：

Pichlmair, Andreas ^{[1
]}

Sousa, Caetano Reis e ^{[1
]}

机构：

[1] London Res Inst, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England

来源：

IMMUNITY | 2007年 / 27卷 / 03期

关键词：

D O I：

10.1016/j.immuni.2007.08.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Virus infection elicits potent responses in all cells intended to contain virus spread before intervention by the adaptive immune system. Central to this process is the virus-elicited production of type I interferons (IFNs) and other cytokines. The sensors involved in coupling recognition of viruses to the induction of the type I IFN genes have only recently been uncovered and include endosomal and cytosolic receptors for RNA and DNA. Here, we review their properties and discuss how their ability to recognize the unusual presence of atypical nucleic acids in particular subcellular compartments is used by the body to detect virus presence.

引用

页码：370 / 383

页数：14

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