Syntheses of oligonucleotide-amino acid conjugates: Using TentaGel and CPG matrices for the synthesis of 3'-phosphoryltyrosine-terminated oligonucleotides

被引:9
作者
Zhao, BP [1 ]
Panigrahi, GB [1 ]
Sadowski, PD [1 ]
Krepinsky, JJ [1 ]
机构
[1] UNIV TORONTO,DEPT MOLEC & MED GENET,TORONTO,ON M5S 1A8,CANADA
关键词
D O I
10.1016/0040-4039(96)00369-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
3'-Phosphoryl-O-tyrosine terminated oligonucleotides were synthesized using controlled-pore glass (CPG) and TentaGel solid matrices. For the synthesis on CPG, the tyrosine hydroxyl was protected with the levulinoyl group which was removed by sodium borohydride. Copyright (C) 1996 Elsevier Science Ltd
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收藏
页码:3093 / 3096
页数:4
相关论文
共 14 条
[1]   SOLID-PHASE SYNTHESIS OF A D-PEPTIDE-PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDE CONJUGATE FROM 2 ARMS OF A POLYETHYLENE GLYCOL-POLYSTYRENE SUPPORT [J].
BASU, S ;
WICKSTROM, E .
TETRAHEDRON LETTERS, 1995, 36 (28) :4943-4946
[2]   TOWARDS THE CHEMICAL SYNTHESIS OF PROTEINS [J].
BAYER, E .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1991, 30 (02) :113-129
[3]   IMPROVED CONDITIONS FOR SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDES ON PS-PEG COPOLYMERS [J].
BAYER, E ;
BLEICHER, K ;
MAIER, M .
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 1995, 50 (07) :1096-1100
[4]   A NOVEL SUICIDE SUBSTRATE FOR DNA TOPOISOMERASES AND SITE-SPECIFIC RECOMBINASES [J].
BURGIN, AB ;
HUIZENGA, BN ;
NASH, HA .
NUCLEIC ACIDS RESEARCH, 1995, 23 (15) :2973-2979
[5]   STEPWISE SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDE-PEPTIDE HYBRIDS [J].
DELATORRE, BG ;
AVINO, A ;
TARRASON, G ;
PIULATS, J ;
ALBERICIO, F ;
ERITJA, R .
TETRAHEDRON LETTERS, 1994, 35 (17) :2733-2736
[6]   THE SYNTHESIS OF POLYAMIDE OLIGONUCLEOTIDE CONJUGATE MOLECULES [J].
HARALAMBIDIS, J ;
DUNCAN, L ;
ANGUS, K ;
TREGEAR, GW .
NUCLEIC ACIDS RESEARCH, 1990, 18 (03) :493-499
[7]   LEVULINIC ESTERS - ALCOHOL PROTECTING GROUP APPLICABLE TO SOME NUCLEOSIDES [J].
HASSNER, A ;
STRAND, G ;
RUBINSTEIN, M ;
PATCHORNIK, A .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (06) :1614-1615
[8]   SYNTHESIS OF NEW UNNATURAL MACROCYCLIC TRICHOTHECENES - 4-EPIVERRUCARIN-A .47. [J].
JEKER, N ;
TAMM, C .
HELVETICA CHIMICA ACTA, 1988, 71 (08) :1904-1913
[9]   SYNTHESIS OF NEW, UNNATURAL MACROCYCLIC TRICHOTHECENES - 3-ISOVERRUCARIN-A ((1''-O)(3-]4)ABEO-VERRUCARIN-A), VERRUCINOL, AND VERRUCENE .46. [J].
JEKER, N ;
TAMM, C .
HELVETICA CHIMICA ACTA, 1988, 71 (08) :1895-1903
[10]   SYNTHESIS OF OLIGOSACCHARIDES BY USING LEVULINIC ESTER AS AN HYDROXYL PROTECTING GROUP [J].
KOENERS, HJ ;
VERHOEVEN, J ;
VANBOOM, JH .
TETRAHEDRON LETTERS, 1980, 21 (04) :381-382