Polyclonal expansion of CD3+/CD4+/CD56+ large granular lymphocytes and autoimmunity associated with dysregulation of Fas/FasL apoptotic pathway

被引：13

作者：

Camagna, A

Cedrone, L

Caré, A

Samoggia, P

De Marco, MC

Del Duca, P

De Martinis, C

Testa, U

机构：

[1] Univ Roma La Sapienza, Dept Clin Sci, I-00161 Rome, Italy

[2] Ist Super Sanita, Lab Haematol & Oncol, I-00161 Rome, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2001年 / 112卷 / 01期

关键词：

apoptosis; autoimmunity; large granular lymphocytes; CD95; polyclonal proliferation;

D O I：

10.1046/j.1365-2141.2001.02483.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Evidence is accumulating regarding CD95/CD95 ligand (Fas/FasL) pathway dysregulation in clonal diseases of the lymphohaemopoietic lineages. According to these observations, it has been proposed that this defect may represent one of the mechanisms of tumour progression. In large granular lymphocyte (LGL) leukaemia, dysregulated apoptosis may represent a key event in the development of malignancy and autoimmunity. This case report describes dysregulation of the Fas/FasL pathway in a chronic polyclonal expansion of CD3(+) LGLs associated with numerous serological immune abnormalities.

引用

页码：204 / 207

页数：4

共 12 条

[1] Membrane-bound Fas (Apo-1/CD95) ligand on leukemic cells: A mechanism of tumor immune escape in leukemia patients [J].