A new central scaffold for metastasis: Parsing HEF1le/Cas-L/NEDD9

被引：94

作者：

O'Neill, Geraldine M.

Seo, Sachiko

Serebriiskii, Hya G.

Lessin, Stuart R.

Golemis, Erica A.

机构：

[1] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

[2] Childrens Hosp Westmead, Oncol Res Unit, Westmead, NSW, Australia

[3] Univ Sydney, Sydney, NSW 2006, Australia

[4] Univ Tokyo, Dept Hematol & Oncol, Grad Sch Med, Tokyo 106, Japan

来源：

CANCER RESEARCH | 2007年 / 67卷 / 19期

关键词：

D O I：

10.1158/0008-5472.CAN-07-1328

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Greater understanding of metastasis is required to improve cancer treatment outcomes. Recently, changes in expression of the scaffold protein IIEF1/CAS-L/NEDD9 were found to be a potent prometastatic stimulus in melanoma and other cancers. Mechanistic studies suggest diverse cellular roles of HEF1 and highlight its importance in the response to extracellular cues that drive invasion and metastasis. As a metastatic "hub" for signaling in cancer, HEF1 may provide a useful target for drug discovery efforts.

引用

收藏

页码：8975 / 8979

页数：5

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