What brings pericytes to tumor vessels?

被引：143

作者：

Jain, RK

Booth, MF

机构：

[1] Harvard Univ, Sch Med, Edwin L Steele Lab, Dept Radiat Oncol, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Edwin L Steele Lab, Dept Radiat Oncol, Boston, MA 02114 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 08期

关键词：

BLOOD-VESSELS; CELLS; INDUCTION; VEGF; ANGIOGENESIS; RECRUITMENT; VASCULATURE; EXPRESSION; PDGF;

D O I：

10.1172/JCI200320087

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Paracrine signaling via platelet-derived growth factor B (PDGFB), expressed by endothelial cells, and its receptor PDGFR-beta, expressed by pericytes, plays a central role in blood vessel maturation. A new study (see the related article beginning on page 1142) reveals that it is not just the presence of PDGFB, but how it is presented to pericytes, that determines the quality of the endothelium-pericyte interaction.

引用

收藏

页码：1134 / 1136

页数：3

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