Microbe-host interacions are positively and negatively regulated by galectin glycan interactions

被引：66

作者：

Baum, Linda G. ^{[1
]}

Garner, Omai B. ^{[1
]}

Schaefer, Katrin ^{[1
]}

Lee, Benhur ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2014年 / 5卷

关键词：

galectin; cell surface glycans; microbial pathogen; virus; bacteria; T-CELL DEATH; PATTERN-RECOGNITION; INNATE IMMUNITY; CANDIDA-ALBICANS; LEISHMANIA-MAJOR; EPITHELIAL-CELLS; NIPAH VIRUS; BINDING; ASSOCIATION; LECTINS;

D O I：

10.3389/fimmu.2014.00284

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Microbe-host interactions are complex processes that are directly and indirectly regulated by a variety of factors, including microbe presentation of specific molecular signatures on the microbial surface, as well as host cell presentation of receptors that recognize these pathogen signatures. Cell surface glycans are one important class of microbial signatures that are recognized by a variety of host cell lectins. Host cell lectins that recognize microbial glycans include members of the galectin family of lectins that recognize specific glycan ligands on viruses, bacteria, fungi, and parasites. In this review, we will discuss the ways that the interactions of microbial glycans with host cell galectins positively and negatively regulate pathogen attachment, invasion, and survival, as well as regulate host responses that mitigate microbial pathogenesis.

引用

页数：8

共 62 条

[1]

Association of Cell Surface Mucins with Galectin-3 Contributes to the Ocular Surface Epithelial Barrier [J].