The effect of the neuroprotective agent riluzole on MRI parameters in primary progressive multiple sclerosis: a pilot study

被引：94

作者：

Kalkers, NF

Barkhof, F

Bergers, E

van Schijndel, R

Polman, C

机构：

[1] VU Med Ctr, Dept Neurol, Magnet Resonance Ctr Multiple Sclerosis Res, NL-1007 MB Amsterdam, Netherlands

[2] VU Med Ctr, Magnet Resonance Ctr Multiple Sclerosis Res, Dept Radiol, NL-1007 MB Amsterdam, Netherlands

[3] VU Med Ctr, Dept Clin Phys & Informat, Magnet Resonance Ctr Multiple Sclerosis Res, NL-1007 MB Amsterdam, Netherlands

来源：

MULTIPLE SCLEROSIS | 2002年 / 8卷 / 06期

关键词：

multiple sclerosis; neuroprotection; riluzole;

D O I：

10.1191/1352458502ms849xx

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Progressive axonal loss is the most likely pothologic correlate of irreversible neurologic impairment in primary progressive multiple sclerosis. In a run-in versus treatment trial, we show that the neuroprotective agent riluzole seems to reduce the rate of cervical cord atrophy and the development of hypointense TI brain lesions on magnetic resonance imaging.

引用

页码：532 / 533

页数：2

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