Synthesis of the carbocyclic core of the cornexistins by ring-closing metathesis

被引：47

作者：

Clark, JS ^{[1
]}

Marlin, F ^{[1
]}

Nay, B ^{[1
]}

Wilson, C ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 01期

关键词：

D O I：

10.1021/ol027265y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An advanced intermediate in the synthesis of the phytotoxins cornexistin and hydroxycornexistin has been synthesized. Sequential palladium-mediated sp(2)-sp(3) fragment coupling and ring-closing diene metathesis have been used to construct the nine-membered carbocyclic core found in the natural products.

引用

页码：89 / 92

页数：4

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