Hesperitin esters: Highly stable flavanones with both free radical scavenging and anti-elastase activities

被引：6

作者：

Boumendjel, A ^{[1
]}

Mariotte, AM

Bresson-Rival, D

Perrier, E

机构：

[1] CNRS, UMR 5063, UFR Pharm Grenoble, Lab Pharmacognosie, F-38706 La Tronche, France

[2] Soc COLETICA, Lyon, France

来源：

PHARMACEUTICAL BIOLOGY | 2003年 / 41卷 / 07期

关键词：

hesperitin; acylation; stability; anti-elastase; free radical scavenging activity;

D O I：

10.1080/13880200308951351

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In targeting molecules destinated for treatment of skin ageing, we synthesized esters of hesperitin (4'-methoxy-5,7,3'-trihydroxyflavanone). Esterification with lauric acid was used with the aim to overcome the flavonoid instability and to improve the therapeutic usefulness. Stability, free radical scavenging activity and anti-elastase potency of the prepared compounds were studied and compared to those of hesperitin (natural compound). Compounds obtained are more stable than hesperitin and display similar or higher antielastolytic and free radical scavenging activities.

引用

页码：546 / 549

页数：4

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