Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides

被引：63

作者：

Coull, JJ

He, GC

Melander, C

Rucker, VC

Dervan, PB

Margolis, DM

机构：

[1] Univ Texas, SW Med Ctr, Div Infect Dis, Dept Med, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Cell & Mol Biol, Dallas, TX 75390 USA

[3] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

[4] N Texas Vet Hlth Care Syst, Dallas, TX 75216 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 23期

关键词：

D O I：

10.1128/JVI.76.23.12349-12354.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The host factor LSF represses the human immunodeficiency virus type 1 long terminal repeat (LTR) by mediating recruitment of histone deacetylase. We show that pyrrole-imidazole polyamides targeted to the LTR can specifically block LSF binding both in vitro and within cells via direct access to chromatin, resulting in increased LTR expression.

引用

页码：12349 / 12354

页数：6

共 18 条

[1] Solid phase synthesis of polyamides containing imidazole and pyrrole amino acids
Baird, EE
Dervan, PB
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (26) : 6141 - 6146
[2] Inhibition of major-groove-binding proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch
Bremer, RE
Baird, EE
Dervan, PB
[J]. CHEMISTRY & BIOLOGY, 1998, 5 (03): : 119 - 133
[3] CYCLIC POLYAMIDES FOR RECOGNITION IN THE MINOR-GROOVE OF DNA
CHO, JY
PARKS, ME
DERVAN, PB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (22) : 10389 - 10392
[4] Quantification of latent tissue reservoirs and total body viral load in HIV-1 Infection
Chun, TW
Carruth, L
Finzi, D
Shen, XF
DiGiuseppe, JA
Taylor, H
Hermankova, M
Chadwick, K
Margolick, J
Quinn, TC
Kuo, YH
Brookmeyer, R
Zeiger, MA
BarditchCrovo, P
Siliciano, RF
[J]. NATURE, 1997, 387 (6629) : 183 - 188
[5] A BIOASSAY FOR HIV-1 BASED ON ENV-CD4 INTERACTION
CIMINALE, V
FELBER, BK
CAMPBELL, M
PAVLAKIS, GN
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1990, 6 (11) : 1281 - 1287
[6] The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1
Coull, JJ
Romerio, F
Sun, JM
Volker, JL
Galvin, KM
Davie, JR
Shi, Y
Hansen, U
Margolis, DM
[J]. JOURNAL OF VIROLOGY, 2000, 74 (15) : 6790 - 6799
[7] Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-κB, and DNA by a designed DNA-binding ligand
Dickinson, LA
Trauger, JW
Baird, EE
Dervan, PB
Graves, BJ
Gottesfeld, JM
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (18) : 12765 - 12773
[8] Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides
Dickinson, LA
Trauger, JW
Baird, EE
Ghazal, P
Dervan, PB
Gottesfeld, JM
[J]. BIOCHEMISTRY, 1999, 38 (33) : 10801 - 10807
[9] ELKHARROUBI A, 1994, J BIOL CHEM, V269, P19916
[10] Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
Finzi, D
Hermankova, M
Pierson, T
Carruth, LM
Buck, C
Chaisson, RE
Quinn, TC
Chadwick, K
Margolick, J
Brookmeyer, R
Gallant, J
Markowitz, M
Ho, DD
Richman, DD
Siliciano, RF
[J]. SCIENCE, 1997, 278 (5341) : 1295 - 1300

← 1 2 →