The Mi-2/NuRD complex A critical epigenetic regulator of hematopoietic development, differentiation and cancer

被引：72

作者：

Ramirez, Julita ^{[1
]}

Hagman, James ^{[1
]}

机构：

[1] Natl Jewish Hlth, Integrated Dept Immunol, Denver, CO USA

来源：

EPIGENETICS | 2009年 / 4卷 / 08期

关键词：

chromatin remodeling; Mi-2; beta; histone deacetylation; histone demethylation; transcription; oncogenesis; leukemogenesis; B cell; T cell; CHROMATIN REMODELER MI-2-BETA; HISTONE DEACETYLASE; NURD COMPLEX; GENE-EXPRESSION; DERMATOMYOSITIS; LSD1; POLYMYOSITIS; REPRESSION; APOPTOSIS; COMPONENT;

D O I：

10.4161/epi.4.8.10108

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Mi-2/NuRD chromatin remodeling complex links multiple transcriptional regulatory processes including histone deacetylation, histone demethylation, nucleosome mobilization and recruitment of other regulatory proteins. In some contexts, Mi-2/NuRD functions as a barrier to transcriptional activation by working in opposition to other chromatin remodelers such as SWI/SNF. Alternatively, the Mi-2 beta ATPase subunit of Mi-2/NuRD can promote transcription. Together, these gatekeeper functions of Mi-2/NuRD influence cell fate decisions by modulating transcriptional activity. Recent studies have shown the importance of Mi-2/NuRD both in maintaining hematopoietic stem cell (HSC) pools and in normal lineage progression. Furthermore, components of Mi-2/NuRD complexes are modular co-repressors/co-activators comprising multiple protein subunits that have been linked directly to oncogenesis and have potential as therapeutic targets for cancer treatment. Mi-2/NuRD's essential functions in metazoan cell fates and activities underscore its importance as a focal point of epigenetic research.

引用

页码：532 / 536

页数：5

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