Streptococcal DNase B is immunologically identical to superantigen SpeF but involves separate domains

被引：14

作者：

Eriksson, A ^{[1
]}

Eriksson, B

Holm, SE

Norgren, M

机构：

[1] Umea Univ, Dept Clin Bacteriol, S-90185 Umea, Sweden

[2] Huddinge Hosp, Karolinska Inst, Dept Immunol, Div Infect Dis, S-14186 Huddinge, Sweden

[3] Huddinge Hosp, Karolinska Inst, Dept Microbiol, Div Infect Dis, S-14186 Huddinge, Sweden

[4] Huddinge Hosp, Karolinska Inst, Dept Pathobiol, Div Infect Dis, S-14186 Huddinge, Sweden

[5] Huddinge Hosp, Karolinska Inst, Dept Infect Dis, Div Infect Dis, S-14186 Huddinge, Sweden

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 1999年 / 6卷 / 01期

关键词：

D O I：

10.1128/CDLI.6.1.133-136.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The previous suggestion that streptococcal superantigen SpeF might be identical to DNase B was confirmed in this study. Polyclonal SpeF-specific antisera were able to inhibit depolymerization of methyl-green DNA by DNase B. However, T-cell mitogenicity and: nuclease activity appear to involve separate immune epitopes on SpeF, since sera with the capacity to neutralize the mitogenic activity of SpeF did not always inhibit the DNase activity.

引用

页码：133 / 136

页数：4

共 23 条

[1] A PROTEOLYTIC ENZYME PRODUCED BY GROUP-A STREPTOCOCCI WITH SPECIAL REFERENCE TO ITS EFFECT ON THE TYPE-SPECIFIC M-ANTIGEN [J].