Signal integration during development:: Insights from the Drosophila eye

被引：141

作者：

Voas, MG

Rebay, I ^{[1
]}

机构：

[1] MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02142 USA

来源：

DEVELOPMENTAL DYNAMICS | 2004年 / 229卷 / 01期

关键词：

Drosophila; Ras; receptor tyrosine kinase; Notch; signal integration; developmental timing; transcription factor; signal transduction; cell fate specification; patterning; development;

D O I：

10.1002/dvdy.10449

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The Drosophila eye is a highly ordered epithelial tissue composed of similar to750 subunits called ommatidia arranged in a reiterated hexagonal pattern. At higher resolution, observation of the constituent photoreceptors, cone cells, and pigment cells of the eye reveals a highly ordered mosaic of amazing regularity. This relatively simple organization belies the repeated requirement for spatially and temporally coordinated inputs from the Hedgehog (Hh), Wingless (Wg), Decapentaplegic (Dpp), JAK-STAT, Notch, and receptor tyrosine kinase (RTK) signaling pathways. This review will discuss how signaling inputs from the Notch and RTK pathways, superimposed on the developmental history of a cell, facilitate context-specific and appropriate cell fate specification decisions in the developing fly eye. Lessons learned from investigating the combinatorial signal integration strategies underlying Drosophila eye development will likely reveal cell-cell communication paradigms relevant to many aspects of invertebrate and mammalian development. (C) 2003 Wiley-Liss, Inc.

引用

页码：162 / 175

页数：14

共 116 条

[1] THE LET-23 GENE NECESSARY FOR CAENORHABDITIS-ELEGANS VULVAR INDUCTION ENCODES A TYROSINE KINASE OF THE EGF RECEPTOR SUBFAMILY [J].