Evolution of mammals and their gut microbes

被引：2730

作者：

Ley, Ruth E. ^{[1
]}

Hamady, Micah ^{[2
]}

Lozupone, Catherine ^{[1
,3
]}

Turnbaugh, Peter J. ^{[1
]}

Ramey, Rob Roy ^{[4
]}

Bircher, J. Stephen ^{[5
]}

Schlegel, Michael L. ^{[6
]}

Tucker, Tammy A. ^{[6
]}

Schrenzel, Mark D. ^{[6
]}

Knight, Rob ^{[3
]}

Gordon, Jeffrey I. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Ctr Genome Sci, St Louis, MO 63108 USA

[2] Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USA

[3] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

[4] Wildlife Sci Int Inc, Nederland, CO 80466 USA

[5] St Louis Zoo, St Louis, MO 63110 USA

[6] Zool Soc San Diego, San Diego, CA 92112 USA

来源：

SCIENCE | 2008年 / 320卷 / 5883期

关键词：

D O I：

10.1126/science.1155725

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mammals are metagenomic in that they are composed of not only their own gene complements but also those of all of their associated microbes. To understand the coevolution of the mammals and their indigenous microbial communities, we conducted a network- based analysis of bacterial 16S ribosomal RNA gene sequences from the fecal microbiota of humans and 59 other mammalian species living in two zoos and in the wild. The results indicate that host diet and phylogeny both influence bacterial diversity, which increases from carnivory to omnivory to herbivory; that bacterial communities codiversified with their hosts; and that the gut microbiota of humans living a modern life- style is typical of omnivorous primates.

引用

页码：1647 / 1651

页数：5

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