Baroreflex modulation of muscle sympathetic nerve activity during posthandgrip muscle ischemia in humans

被引:69
作者
Cui, J
Wilson, TE
Shibasaki, M
Hodges, NA
Crandall, CG
机构
[1] Presbyterian Med Ctr, Inst Exercise & Environm Med, Dallas, TX 75231 USA
[2] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA
关键词
metaboreceptor; baroreflex sensitivity; heart rate; exercise;
D O I
10.1152/jappl.2001.91.4.1679
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
To identify whether muscle metaboreceptor stimulation alters baroreflex control of muscle sympathetic nerve activity (MSNA), MSNA, beat-by-beat arterial blood pressure (Finapres), and electrocardiogram were recorded in 11 healthy subjects in the supine position. Subjects performed 2 min of isometric handgrip exercise at 40% of maximal voluntary contraction followed by 2.5 min of posthandgrip muscle ischemia. During muscle ischemia, blood pressure was lowered and then raised by intravenous bolus infusions of sodium nitroprusside and phenylephrine HCl, respectively. The slope of the relationship between MSNA and diastolic blood pressure was more negative (P < 0.001) during posthandgrip muscle ischemia (-201.9 +/- 20.4 units.beat(-1).mmHg(-1)) when compared with control conditions (- 142.7 +/- 17.3 units.beat(-1).mmHg(-1)). No significant change in the slope of the relationship between heart rate and systolic blood pressure was observed. However, both curves shifted during postexercise ischemia to accommodate the elevation in blood pressure and MSNA that occurs with this condition. These data suggest that the sensitivity of baroreflex modulation of MSNA is elevated by muscle metaboreceptor stimulation, whereas the sensitivity of baroreflex of modulate heart rate is unchanged during posthandgrip muscle ischemia.
引用
收藏
页码:1679 / 1686
页数:8
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