The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis

被引：738

作者：

Cardone, RA ^{[1
]}

Casavola, V ^{[1
]}

Reshkin, SJ ^{[1
]}

机构：

[1] Univ Bari, Dept Gen & Environm Physiol, I-70126 Bari, Italy

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 10期

关键词：

D O I：

10.1038/nrc1713

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microenvironment in malignant invasion. This microenvironment is acidified primarily by the tumour-cell Na+/H+ exchanger NHE1 and the H+/lactate cotransporter, which are activated in cancer cells. NHE1 also regulates formation of invadopodia - cell structures that mediate tumour cell migration and invasion. How do these alterations of the metabolic microenvironment and cell invasiveness contribute to tumour formation and progression?

引用

页码：786 / 795

页数：10

共 79 条

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