Tn125-Related Acquisition of blaNDM-Like Genes in Acinetobacter baumannii

被引:165
作者
Poirel, Laurent [1 ,2 ]
Bonnin, Remy A. [1 ,2 ]
Boulanger, Anne [1 ,2 ]
Schrenzel, Jacques [3 ,4 ]
Kaase, Martin [5 ]
Nordmann, Patrice [1 ,2 ]
机构
[1] Hop Bicetre, AP HP, INSERM U914, Serv Bacteriol Virol,Fac Med, K Bicetre, France
[2] Univ Paris 11, K Bicetre, France
[3] Univ Hosp Geneva, Bacteriol Lab, Geneva, Switzerland
[4] Univ Hosp Geneva, Genom Res Lab, Geneva, Switzerland
[5] Univ Bochum, Natl Reference Lab Multidrug Resistant Gram Negat, Dept Med Microbiol, Bochum, Germany
关键词
ESCHERICHIA-COLI; CARBAPENEMASE; RESISTANCE; STRAIN; PREVALENCE; BLA(NDM-1); ELEMENTS;
D O I
10.1128/AAC.05620-11
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
A multidrug-resistant Acinetobacter baumannii isolate recovered from a patient hospitalized in Switzerland after a transfer from Serbia produced the NDM-1 carbapenemase. The bla(NDM-1) gene was part of a chromosomally located Tn125 composite transposon bracketed by two copies of the same insertion sequence, ISAba125. This transposon was also associated with the acquisition and expression of the bla(NDM-2) gene in an A. baumannii isolate in Germany. Tn125 appears to be the main vehicle for dissemination of bla(NDM) genes in that species.
引用
收藏
页码:1087 / 1089
页数:3
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