Changes in the rate of genotypic resistance to antiretroviral drugs in Spain

被引：38

作者：

Gallego, O ^{[1
]}

Ruiz, L

Vallejo, A

Ferrer, E

Rubio, A

Clotet, B

Leal, M

Soriano, V

机构：

[1] Inst Salud Carlos III, Madrid, Spain

[2] Fdn IrsiCaixa, Barcelona, Spain

[3] Hosp Virgen Rocio, Seville, Spain

来源：

AIDS | 2001年 / 15卷 / 14期

关键词：

D O I：

10.1097/00002030-200109280-00025

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genotypic resistance to antiretroviral drugs was examined in 684 individuals attending 18 outpatient clinics distributed across Spain in June 2000. Compared with similar surveys conducted before 1998, the prevalence of resistance to nucleosides has declined significantly among naive chronic HIV carriers. In contrast, resistance among pre-treated patients has increased; resistance to all three drug families having been recognized in nearly a quarter of patients.

引用

页码：1894 / 1896

页数：3

共 12 条

[1] Prevalence of drug-resistant HIV-1 genotypes in heavily pre-treated patients on current virological failure [J].

Briones, C ;

Soriano, V ;

González-Lahoz, J .

AIDS, 2000, 14 (11) :1659-1660

[2] Prevalence of genotypic resistance to nucleoside analogues in antiretroviral-naive and antiretroviral-experienced HIV-infected patients in Spain [J].

Gomez-Cano, M ;

Rubio, A ;

Puig, T ;

Perez-Olmeda, M ;

Ruiz, L ;

Soriano, V ;

Pineda, JA ;

Zamora, L ;

Xaus, N ;

Clotet, E ;

Leal, M .

AIDS, 1998, 12 (09) :1015-1020

[3] Antiretroviral drug resistance testing in adult HIV-1 infection -: Recommendations of an International AIDS Society-USA panel [J].

Hirsch, MS ;

Brun-Vézinet, F ;

D'Aquila, RT ;

Hammer, SM ;

Johnson, VA ;

Kuritzkes, DR ;

Loveday, C ;

Mellors, JW ;

Clotet, B ;

Conway, B ;

Demeter, LM ;

Vella, S ;

Jacobsen, DM ;

Richman, DD .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (18) :2417-2426

[4]

Pérez-Olmeda M, 2001, J MED VIROL, V63, P85, DOI 10.1002/1096-9071(20000201)63:2&lt

[5]

85::AID-JMV1000&gt

[6]

3.0.CO

[7]

2-M

[8] Prevalence of genotypic resistance to nucleoside analogues and protease inhibitors in Spain [J].

Puig, T ;

Pérez-Olmeda, M ;

Rubio, A ;

Ruiz, L ;

Briones, C ;

Franco, JM ;

Gómez-Cano, M ;

Stuyver, L ;

Zamora, L ;

Alvarez, C ;

Leal, M ;

Clotet, B ;

Soriano, V .

AIDS, 2000, 14 (06) :727-732

[9] Viral load and heterosexual transmission of human immunodeficiency virus type 1 [J].

Quinn, TC ;

Wawer, MJ ;

Sewankambo, N ;

Serwadda, D ;

Li, CJ ;

Wabwire-Mangen, F ;

Meehan, MO ;

Lutalo, T ;

Gray, RH .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (13) :921-929

[10] Line probe assay for rapid detection of drug-selected mutations in the human immunodeficiency virus type 1 reverse transcriptase gene [J].

Stuyver, L ;

Wyseur, A ;

Rombout, A ;

Louwagie, J ;

Scarcez, T ;

Verhofstede, C ;

Rimland, D ;

Schinazi, RF ;

Rossau, R .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (02) :284-291

← 1 2 →