tACS motor system effects can be caused by transcutaneous stimulation of peripheral nerves

被引:190
作者
Asamoah, Boateng [1 ]
Khatoun, Ahmad [1 ]
Mc Laughlin, Myles [1 ]
机构
[1] Katholieke Univ Leuven, Dept Neurosci, Exp ORL, B-3000 Leuven, Belgium
关键词
ALTERNATING-CURRENT STIMULATION; SOMATOSENSORY-EVOKED POTENTIALS; STEADY-STATE; ELECTRICAL-STIMULATION; VISUAL-CORTEX; SYNCHRONIZATION; RESPONSES; FIELDS; TREMOR;
D O I
10.1038/s41467-018-08183-w
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation method which has been shown to modulate hearing, motor, cognitive and memory function. However, the mechanisms underpinning these findings are controversial, as studies show that the current reaching the cortex may not be strong enough to entrain neural activity. Here, we propose a new hypothesis to reconcile these opposing results: tACS effects are caused by transcutaneous stimulation of peripheral nerves in the skin and not transcranial stimulation of cortical neurons. Rhythmic activity from peripheral nerves then entrains cortical neurons. A series of experiments in rats and humans isolated the transcranial and transcutaneous mechanisms and showed that the reported effects of tACS on the motor system can be caused by transcutaneous stimulation of peripheral nerves. Whether or not the transcutaneous mechanism will generalize to tACS effects on other systems is debatable but should be investigated.
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页数:16
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