Chronic kidney disease

被引：1545

作者：

Levey, Andrew S. ^{[1
]}

Coresh, Josef ^{[2
]}

机构：

[1] Tufts Med Ctr, William B Schwartz Div Nephrol, Boston, MA 02111 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

来源：

LANCET | 2012年 / 379卷 / 9811期

关键词：

GLOMERULAR-FILTRATION-RATE; CLINICAL-PRACTICE GUIDELINES; BLOOD-PRESSURE CONTROL; SERUM CYSTATIN-C; QUALITY-OF-LIFE; POSITION STATEMENT; CARDIOVASCULAR EVENTS; COLLABORATIVE METAANALYSIS; HIGHER ALBUMINURIA; MEDICAL PROGRESS;

D O I：

10.1016/S0140-6736(11)60178-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic kidney disease is a general term for heterogeneous disorders affecting kidney structure and function. The 2002 guidelines for definition and classification of this disease represented an important shift towards its recognition as a worldwide public health problem that should be managed in its early stages by general internists. Disease and management are classified according to stages of disease severity, which are assessed from glomerular filtration rate (GFR) and albuminuria, and clinical diagnosis (cause and pathology). Chronic kidney disease can be detected with routine laboratory tests, and some treatments can prevent development and slow disease progression, reduce complications of decreased GFR and risk of cardiovascular disease, and improve survival and quality of life. In this Seminar we discuss disease burden, recommendations for assessment and management, and future challenges. We emphasise clinical practice guidelines, clinical trials, and areas of uncertainty.

引用

页码：165 / 180

页数：16

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