Association of health-related quality of life and benign prostatic enlargement

被引:57
作者
Girman, CJ
Jacobsen, SJ
Rhodes, T
Guess, HA
Roberts, RO
Lieber, MM
机构
[1] Mayo Clin, Dept Hlth Serv Res, Rochester, MN USA
[2] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA
[3] Univ N Carolina, Dept Biostat, Chapel Hill, NC USA
[4] Mayo Clin, Dept Urol, Rochester, MN USA
[5] Merck Res Labs, Dept Epidemiol, West Point, PA USA
关键词
lower urinary tract symptoms; prostatic hypertrophy; quality of life; prostate size; community study; epidemiology;
D O I
10.1159/000019861
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objective: To investigate the association of benign prostatic enlargement and health-related quality of life (HRQoL) assessed by validated questionnaires, Method: Randomly selected men (n = 471) aged 40-79 years from Olmsted County, Minn. (USA) without prior prostate surgery or prostate cancer had a full urologic workup, including transrectal ultrasonography, in addition to completing questionnaires soliciting information about urinary symptom frequency, bother, degree of interference with daily activities and other measures of HRQoL. Results: Disease-specific HRQoL was worse in older men, and men with more severe symptoms. Age-adjusted mean scores for symptom severity, bother and activity interference were about 50% worse for men with enlarged prostates (volume > 40 cm(3)). After adjusting for age, men with enlarged prostates were nearly 3 times (95% CI 1.6, 5.1) as likely to have moderate to severe symptoms, and about twice as likely to have bother (odds ratio 2.4; 95% CI 1.3, 4.2) or activity interference (odds ratio 1.8; 95% CI 1.0, 3.2) relative to men with smaller prostates. Conclusion: HRQoL measures are worse in men who are older and, after adjusting for age, in men with increased urinary symptom frequency and enlarged prostate. The broader spectrum of patients provided by the community-based random sampling allows elucidation of these important relationships.
引用
收藏
页码:277 / 284
页数:8
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