Differential expression of cytokines in the brain and serum during endotoxin tolerance

被引：53

作者：

Chen, R ^{[1
]}

Zhou, HP ^{[1
]}

Beltran, J ^{[1
]}

Malellari, L ^{[1
]}

Chang, SL ^{[1
]}

机构：

[1] Seton Hall Univ, Dept Biol, S Orange, NJ 07079 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 163卷 / 1-2期

关键词：

lipopolysaccharide; cytokine; inflammation; corticosterone; brain;

D O I：

10.1016/j.jneuroim.2005.02.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Using short- and long-course lipopolysaccharide (LPS) treatment regimens to induce endotoxin tolerance in rats, we compared TNF-alpha, IL-1 beta, and IL-6 expression in the brain and serum following a LPS challenge. Serum corticosterone was also examined to evaluate the function of the hypothalamic-pituitary-adrenal (HPA) axis. We found that, during endotoxin tolerance, LPS-induced cytokine expression still occurred in the brain even when cytokines in the periphery were no longer induced, and that this differential cytokine expression may be mediated by corticosterone, a stress hormone and an anti-inflammatory agent. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：53 / 72

页数：20

共 34 条

[1]

Anisman H, 1998, Stress, V2, P209

[2]

PRETREATMENT OF NORMAL HUMANS WITH MONOPHOSPHORYL LIPID-A INDUCES TOLERANCE TO ENDOTOXIN - A PROSPECTIVE, DOUBLE-BLIND, RANDOMIZED, CONTROLLED TRIAL [J].