Role of intestinal inflammation as an early event in obesity and insulin resistance

被引：150

作者：

Ding, Shengli ^{[1
]}

Lund, Pauline K. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Cell & Mol Physiol, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC 27599 USA

来源：

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE | 2011年 / 14卷 / 04期

基金：

美国国家卫生研究院;

关键词：

cytokines; diet-induced obesity; high-fat diet; insulin resistance; intestinal inflammation; DIET-INDUCED OBESITY; GLUCAGON-LIKE PEPTIDE-1; GUT MICROBIOTA; GLUCOSE-TOLERANCE; ENDOTOXEMIA; OLIGOFRUCTOSE; IMPROVEMENT; METABOLISM; MODULATION; MICE;

D O I：

10.1097/MCO.0b013e3283478727

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review To highlight recent evidence supporting a concept that intestinal inflammation is a mediator or contributor to development of obesity and insulin resistance. Recent findings Current views suggest that obesity-associated systemic and adipose tissue inflammation promote insulin resistance, which underlies many obesity-linked health risks. Diet-induced changes in gut microbiota also contribute to obesity. Recent findings support a concept that high-fat diet and bacteria interact to promote early inflammatory changes in the small intestine that contribute to development of or susceptibility to obesity and insulin resistance. This review summarizes the evidence supporting a role of intestinal inflammation in diet-induced obesity and insulin resistance and discusses mechanisms. Summary The role of diet-induced intestinal inflammation as an early biomarker and mediator of obesity, and insulin resistance warrants further study.

引用

收藏

页码：328 / 333

页数：6

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