Chemical constituents from Lippia sidoides and cytotoxic activity

被引：52

作者：

Costa, SMO

Lemos, TLG

Pessoa, ODL

Pessoa, C

Montenegro, RC

Braz-Filho, R

机构：

[1] Univ Fed Ceara, Dept Quim Organ & Inorgan, BR-60451970 Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, Dept Fisiol & Farmacol, BR-60430270 Fortaleza, Ceara, Brazil

[3] Univ Estadual Norte Fluminense, LCQUI CCT, Setor Quim Prod Nat, BR-28015620 Campos, Rio De Janeiro, Brazil

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 06期

关键词：

D O I：

10.1021/np0005917

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eleven known compounds and a new prenylated naphthoquinone, lippsidoquinone (13), were isolated from ethanol extracts of Lippia sidoides. Their structures were established by a combination of 1D and 2D NMR, IR, and EIMS spectral data analysis. The cytotoxic properties of compounds 3-13 were evaluated against HL60, SW1573, and CEM cell lines. Only tectol (6) and lippsidoquinone (13) exhibited significant activity against human leukemia cell lines HL60 and CEM.

引用

页码：792 / 795

页数：4

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