A Drosophila model of mitochondrial DNA replication:: Proteins, genes and regulation

被引：18

作者：

Garesse, R

Kaguni, LS

机构：

[1] Univ Autonoma Madrid, Fac Med, CSIC UAM, Inst Invest Biomed Alberto Sols,Dept Bioquim, Madrid, Spain

[2] Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48824 USA

来源：

IUBMB LIFE | 2005年 / 57卷 / 08期

关键词：

Drosophila; mitochondrial DNA replication;

D O I：

10.1080/15216540500215572

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial biogenesis is a critical process in animal development, cellular homeostasis and aging. Mitochondrial DNA replication is an essential part of this process, and both nuclear and mitochondrial DNA mutations are found to result in mitochondrial dysfunction that leads to developmental defects and delays, aging and disease. Drosophila provides an amenable model system to study mitochondrial biogenesis in normal and disease states. This review provides an overview of current approaches to study the proteins involved in mitochondrial DNA replication, the genes that encode them and their regulation. It also presents a survey of cell and animal models under development to mimic the pathophysiology of human mitochondrial disorders.

引用

收藏

页码：555 / 561

页数：7

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