T-cell repertoire: Political correctness in the immune system

被引:7
作者
Lucas, B
Germain, RN
机构
[1] Laboratory of Immunology, Natl. Inst. Allerg. and Infect. Dis., National Institutes of Health, Bethesda
关键词
D O I
10.1016/S0960-9822(02)00594-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent studies of T-cell development in various types of mutant mouse shed new light on the relative roles in T-cell selection of antigen verses MHC molecule recognition by T-cell receptors.
引用
收藏
页码:783 / 787
页数:5
相关论文
共 12 条
[1]   PEPTIDE CONTRIBUTES TO THE SPECIFICITY OF POSITIVE SELECTION OF CD8+ T-CELLS IN THE THYMUS [J].
ASHTONRICKARDT, PG ;
VANKAER, L ;
SCHUMACHER, TNM ;
PLOEGH, HL ;
TONEGAWA, S .
CELL, 1993, 73 (05) :1041-1049
[2]  
BEVAN JB, 1994, SCIENCE, V264, P795
[3]   Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression [J].
Chang, CH ;
Guerder, S ;
Hong, SC ;
vanEwijk, W ;
Flavell, RA .
IMMUNITY, 1996, 4 (02) :167-178
[4]   Antigen presentation and T cell development in H2-M-deficient mice [J].
FungLeung, WP ;
Surh, CD ;
Liljedahl, M ;
Pang, J ;
Leturcq, D ;
Peterson, PA ;
Webb, SR ;
Karlsson, L .
SCIENCE, 1996, 271 (5253) :1278-1281
[5]   IMMUNOLOGY - MAKING A MOLECULAR MATCH [J].
GERMAIN, RN .
NATURE, 1990, 344 (6261) :19-22
[6]   POSITIVE SELECTION OF CD8+ T-CELLS INDUCED BY MAJOR HISTOCOMPATIBILITY COMPLEX BINDING PEPTIDES IN FETAL THYMIC ORGAN-CULTURE [J].
HOGQUIST, KA ;
GAVIN, MA ;
BEVAN, MJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (05) :1469-1473
[7]   The repertoire of T cells shaped by a single MHC/peptide ligand [J].
Ignatowicz, L ;
Kappler, J ;
Marrack, P .
CELL, 1996, 84 (04) :521-529
[8]   STOCHASTIC CORECEPTOR SHUTOFF IS RESTRICTED TO THE CD4 LINEAGE MATURATION PATHWAY [J].
LUCAS, B ;
VASSEUR, F ;
PENIT, C .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (05) :1623-1633
[9]   H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection [J].
Martin, WD ;
Hicks, GG ;
Mendiratta, SK ;
Leva, HI ;
Ruley, HE ;
VanKaer, L .
CELL, 1996, 84 (04) :543-550
[10]   Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway [J].
Miyazaki, T ;
Wolf, P ;
Tourne, S ;
Waltzinger, C ;
Dierich, A ;
Barois, N ;
Ploegh, H ;
Benoist, C ;
Mathis, D .
CELL, 1996, 84 (04) :531-541