Genetic Epidemiology 7 - Genetic epidemiology and public health: hope, hype, and future prospects

被引：187

作者：

Smith, GD

Ebrahim, S

Lewis, S

Hansell, AL

Palmer, LJ

Burton, PR

机构：

[1] Univ Bristol, Dept Med Sociol, Bristol BS8 2PR, Avon, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol, London, England

[3] Univ Western Australia, Sch Populat Hlth, Lab Genet Epidemiol, Perth, WA 6009, Australia

[4] Univ Western Australia, Western Australia Inst Med Res, Perth, WA 6009, Australia

[5] Univ Western Australia, Med Res Ctr, Perth, WA 6009, Australia

[6] Univ Leicester, Dept Hlth Sci & Genet, Leicester, Leics, England

来源：

LANCET | 2005年 / 366卷 / 9495期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0140-6736(05)67601-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genetic epidemiology is a rapidly expanding research field, but the implications of findings from such studies for individual or population health are unclear. The use of molecular genetic screening currently has some legitimacy in certain monogenic conditions, but no established value with respect to common complex diseases. Personalised medical care based on molecular genetic testing is also as yet undeveloped for common diseases. Genetic epidemiology can contribute to establishing the causal nature of environmentally modifiable risk factors, throught the application of mendelian randomisation approaches and thus contribute to appropriate preventive strategies. Technological and other advances will allow the potential of genetic epidemiology to be revealed over the next few years, and the establishment of large population-based resources for such studies (biobanks) should contribute to this endeavour.

引用

页码：1484 / 1498

页数：15

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