Mosquito Defense Strategies against Viral Infection

被引：150

作者：

Cheng, Gong ^{[1
]}

Liu, Yang ^{[1
,2
]}

Wang, Penghua ^{[3
]}

Xiao, Xiaoping ^{[1
]}

机构：

[1] Tsinghua Univ, Sch Med, Collaborat Innovat Ctr Diag & Treatment Infect Di, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China

[3] New York Med Coll, Sch Med, Dept Microbiol & Immunol, Valhalla, NY 10595 USA

来源：

TRENDS IN PARASITOLOGY | 2016年 / 32卷 / 03期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

NILE VIRUS-INFECTION; COMPLEMENT-LIKE PROTEIN; JAK-STAT PATHWAY; RNA INTERFERENCE; DENGUE VIRUS; ANTIVIRAL RESPONSE; VECTOR COMPETENCE; ANOPHELES-GAMBIAE; ANTIMICROBIAL PEPTIDES; CULEX-QUINQUEFASCIATUS;

D O I：

10.1016/j.pt.2015.09.009

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Mosquito-borne viral diseases are a major concern of global health and result in significant economic losses in many countries. As natural vectors, mosquitoes are very permissive to and allow systemic and persistent arbovirus infection. Intriguingly, persistent viral propagation in mosquito tissues neither results in dramatic pathological sequelae nor impairs the vectorial behavior or lifespan, indicating that mosquitoes have evolved mechanisms to tolerate persistent infection and developed efficient antiviral strategies to restrict viral replication to nonpathogenic levels. Here we provide an overview of recent progress in understanding mosquito antiviral immunity and advances in the strategies by which mosquitoes control viral infection in specific tissues.

引用

页码：177 / 186

页数：10

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