Gastrointestinal stem cells. II. Intestinal stem cells

被引：96

作者：

Bjerknes, M ^{[1
]}

Cheng, H ^{[1
]}

机构：

[1] Univ Toronto, Div Clin Sci, Dept Med, Toronto, ON M5S 1A8, Canada

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2005年 / 289卷 / 03期

关键词：

progenitor; crypt; epithelium; lineage; crypt base columnar cell;

D O I：

10.1152/ajpgi.00160.2005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Current views of the identity, distribution, and regulation of small intestinal epithelial stem cells and their immediate progeny are discussed. Recent works implicating Wnt signaling in stem and progenitor proliferation, the involvement of Notch signaling in epithelial lineage specification, and the role of hedgehog and bone morphogenetic protein families in crypt formation are integrated. We had the good fortune that many of these papers came in pairs from independent groups. We attempt to identify points of agreement, reinterpret each in the context of the other, and indicate directions for continued progress.

引用

页码：G381 / G387

页数：7

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