Sleep attacks and antiparkinsonian drugs: A pilot prospective pharmacoepidemiologic study

被引：71

作者：

Montastruc, JL ^{[1
]}

Brefel-Courbon, C ^{[1
]}

Senard, JM ^{[1
]}

Bagheri, H ^{[1
]}

Ferreira, J ^{[1
]}

Rascol, O ^{[1
]}

Lapeyre-Mestre, M ^{[1
]}

机构：

[1] CHU Toulouse, Fac Med Toulouse, Serv Pharmacol Clin,Ctr Invest Clin, Ctr Midi Pyrenees Pharmacovigilance Pharmacoepide, F-31073 Toulouse, France

来源：

CLINICAL NEUROPHARMACOLOGY | 2001年 / 24卷 / 03期

关键词：

sleep; sleep attacks; Parkinson's disease; ropinirole; bromocriptine;

D O I：

10.1097/00002826-200105000-00013

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A prospective sun ey was performed to characterize the prevalence of sleep attacks and to evaluate precipitating factors in a group of 236 patients with idiopathic Parkinson's disease. Sleep attacks were reported by 72 patients (30.5%). Multivariate analysis showed a marked association between the occurrence of sudden sleep episodes and first autonomic failure, followed by treatment with ropinirole and bromocriptine. The present work underlines the major contributing role of autonomic failure followed by dopamine agonists in the occurrence of such an event. Because a relationship between sleep attacks and not only ropinirole but also bromocriptine treatment was described, the present work suggests that sleep attacks are a common side effect of all dopamine agonists.

引用

页码：181 / 183

页数：3

共 17 条

[1] L-Dopa-induced sedation:: a double-blind cross-over controlled study versus triazolam and placebo in healthy volunteers [J].