Dynamic Covalent Chemistry Enables Reconfigurable All-Polysaccharide Nanogels

被引:15
作者
Abdi, Fatma [1 ]
Michel, Raphael [1 ]
Poirot, Robin [1 ]
Dakir, Malika [2 ]
Sancey, Lucie [2 ]
Ravaine, Valerie [3 ]
Auzely-Velty, Rachel [1 ]
机构
[1] Univ Grenoble Alpes, CERMAV CNRS, 601 Rue Chim,BP 53, F-38041 Grenoble, France
[2] Univ Grenoble Alpes, Inst Adv Biosci, CNRS, INSERM,U1209,UMR5309, F-38700 La Tronche, France
[3] Univ Bordeaux, CNRS, UMR 5255, INP, Site ENSCBP 16 Ave Pey Berland, F-33607 Pessac, France
关键词
dynamic covalent bonds; molecular recognition; polysaccharides; responsive nanogels; HYALURONIC-ACID; NANOPARTICLES; COMPLEXATION; FABRICATION; DELIVERY; PH;
D O I
10.1002/marc.202000213
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 [高分子化学与物理];
摘要
Dynamic covalent bonds are established upon molecular recognition of sugar derivatives by boronic acid molecules. These reversible links can be used in a cross-linking method to fabricate polymer-based responsive nanosystems. Herein, the design of the first dynamic nanogels made entirely of polysaccharides (PS) is reported. Based on PS chains alternately modified with phenyl boronic acid groups and sugar moieties, these colloids self-assemble in physiological conditions and combine the biocompatible nature of their PS backbone with the reconfiguration capacities of their cross-linking chemistry. These dynamic nanogels are easily prepared, stable for a long time, pH responsive, and efficiently internalized by cancer cells.
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页数:7
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