Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy

被引：1702

作者：

Jain, RK ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Steele Lab, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

来源：

NATURE MEDICINE | 2001年 / 7卷 / 09期

关键词：

D O I：

10.1038/nm0901-987

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anti-angiogenic therapy was proposed in 1971 as a means to treat solid tumors and in 1976 as a method of cancer prevention. Here we propose that this form of therapy, judiciously applied, can normalize the tumor vasculature and improve the delivery of therapeutics.

引用

页码：987 / 989

页数：3

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