Biological and pharmacological activities of iridoids: Recent developments

被引：254

作者：

Tundis, Rosa ^{[1
]}

Loizzo, Monica R. ^{[1
]}

Menichini, Federica ^{[1
]}

Statti, Giancarlo A. ^{[1
]}

Menichini, Francesco ^{[1
]}

机构：

[1] Univ Calabria, Fac Pharm Nutr & Hlth Sci, Dept Pharmaceut Sci, I-87036 Arcavacata Di Rende, CS, Italy

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 04期

关键词：

iridoids; secoiridoids; neuroprotection; antitumor; anti-inflammatory; aglycones; glycosides; other biological properties;

D O I：

10.2174/138955708783955926

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Iridoids represent a large group of cyclopenta[c] pyran monoterpenoids that occur wide-spread in nature, mainly in dicotyledonous plant families like Apocynaceae, Scrophulariaceae, Diervillaceae, Lamiaceae, Loganiaceae and Rubiaceae. Recently, more extensive studies revealed that iridoids exhibit a wide range of bioactivity, such as neuroprotective, antinflammatory and immunomodulator, hepatoprotective and cardioprotective effects. Anticancer, antioxidant, antimicrobic, hypoglycaemic, hypolipidemic, choleretic, antispasmodic and purgative properties were also reported. The aim of the present review is to discuss the recent developments on biological and pharmacological activities of iridoids, supporting the new therapeutic possibilities for the use of these compounds.

引用

页码：399 / 420

页数：22

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