Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume

被引：21

作者：

Peters, LL

Zhang, WD

Lambert, AJ

Brugnara, C

Churchill, GA

Platt, OS

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

[2] Harvard Univ, Sch Med, Childrens Hosp, Dept Lab Med, Boston, MA 02115 USA

来源：

MAMMALIAN GENOME | 2005年 / 16卷 / 10期

关键词：

D O I：

10.1007/s00335-005-0063-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A substantial genetic contribution to baseline peripheral blood counts has been established. We performed quantitative trait locus/loci (QTL) analyses to identify chromosome (Chr) regions harboring genes influencing the baseline white blood cell (WBC) count, platelet (Plt) count, and mean platelet volume (MPV) in F-2 intercrosses between NZW/ LacJ, SM/J, and C57BLKS/J inbred mice. We identified six significant WBC QTL: Wbcq1 (peak LOD score at 38 cM, Chr 1), Wbcq2 (42 cM, Chr 3), Wbcq3 (0 cM, Chr 15), Wbcq4 (58 cM, Chr 1), Wbcq5 (82 cM, Chr 1), and Wbcq6 (8 cM, Chr 14). Three significant Plt QTL were identified: Pltq1 (24 cM, Chr 2), Pltq2 (36 cM, Chr 7), and Pltq3 (10 cM, Chr 12). Two significant MPV QTL were identified, Mpvq1 (62 cM, Chr 15) and Mpvq2 (44 cM, Chr 8). In total, the WBC QTL accounted for up to 31% of the total variance in baseline WBC count, while the Plt and MPV QTL accounted for up to 30% and 49% of the total variance, respectively. These analyses underscore the genetic complexity underlying these traits in normal populations and provide the basis for future studies to identify novel genes involved in the regulation of mammalian hematopoiesis.

引用

页码：749 / 763

页数：15

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